STALIF M Ti™
With Ti ACTIVE™ Titanium-Enhanced PEEK Technology
Sixth generation STALIF® technology, STALIF M-Ti™ incorporates a novel, circumferential, titanium surface, PEEK Integrated Interbody™ design that is raising the Gold Standard of lumbar interbody fusion.
* The device system is designed for use with autograft bone and/or allogenic bone graft composed of cancellous and/or corticocancellous bone graft, to facilitate fusion.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f716c_hero_midlineii-ti_devicescrewsfluoro.png)
Optimized Surface Technology.1
Raising the Standard with Ti ACTIVE™
The Ti-ACTIVE™ surface provides a three-dimensional texturized surface that is microporous with hydrophilic properties, to facilitate human mesenchymal stem cell (hMSC) attachment and proliferation as demonstrated by pre-clinical testing performed on representative PEEK coupons with Ti-ACTIVE surface.2
During manufacturing, commercially pure titanium (CP Ti) is applied to the PEEK cage by a plasma spray to create our Ti-ACTIVE devices. The unique CP Ti surface system utilizes a robotic applicator, enabling the creation of a high-quality, reproducible titanium surface.3 Ti-ACTIVE was tested for mechanical integrity and the results exceeded the FDA requirements for shear and tensile strength for metallic spray surfaces.4
1 Lebl DR. Mechanical performance of cervical TDRs in vivo. Spine (Phila, PA 1976) 2012 Dec 15; 37(26): 2151-60.
2 Yoon BJV, Cammisa FP, Abjornson C. Polishing methods less a factor in cell adhesion than surface characteristics of titanium plasma spray surfaces on PEEK. Paper presented at Lumbar Spine Research Society Meeting, 2015 April, Chicago, IL.
3 Centinel Spine Report VAL-2013-043.
4 Centinel Spine Report CD12-03-07-020.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f7128_hero_ti-active_comparison.jpg)
Texturized Titanium Surface1
SEM image (2,000x magnification) of the surface of a standard PEEK implant (left) and a titanium-applied PEEK implant (right). Unlike standard PEEK, the PEEK with titanium surface provides a 3-D microporous environment conducive to cell attachment and cell migration, seen by cytoplasmic expansions of the cultured cells, as highlighted in purple.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f7126_hero_c-ti_tiactivehmsc.jpg)
Cell Proliferation
SEM image (2,000x magnification) showing cellular interaction allowing human mesenchymal stem cells (hMSCs) to communicate when receptors and markers bind on a Ti-ACTIVE™ surface. Cell to cell interactions are vital in the promotion of cell adhesion and later the function of the cell to differentiate and proliferate, as highlighted in yellow. Ti-ACTIVE™ offers an optimized surface topography enabling cellular migration, cellular interaction, and cellular attachment to the surface as observed on representative STALIF® coupons with Ti-ACTIVE™ surface.2
Integrally PEEK.
Blending the Benefits of Titanium and PEEK
By preserving its PEEK roots, STALIF M-Ti™ exhibits a modulus of elasticity similar to bone. In doing so, the device presents a reduced risk of subsidence relative to all-titanium cages.5 Additionally, STALIF M-Ti™ continues to maintain the radiolucent advantage of PEEK.
5Ashman RB, et al. A continuous wave technique for the measurement of the elastic properties of cortical bone. J Biomech, 1984; 17(5):349-61.
6Chen Y, Wang X, et al. Comparison of titanium and polyetheretherketone (PEEK) cages in the surgical treatment of multilevel cervical spondylotic myelopathy: A prospective, randomized, control study with over 7-year follow-up. Eur Spine J, 2013; http://dx.doi.org/10.1007/s00586-013-2772-y.
7Centinel Spine Report VAL-2014-009.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f71dd_stalif_m-ti-radiolucent-advantage.png)
Radiolucent Advantage
The STALIF M-Ti™ device maintains the radiolucent advantage of PEEK, making it easier to assess post-operative development of fusion mass during follow-up.7 The Ti-ACTIVE™ surface allows for radiographic visualization of the graft-endplate contact. Images show radiographs of STALIF M-Ti™ in Anterior/Posterior view (left) and Lateral view (right).
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f7127_hero_c-ti_elasticmodulus_v2.png)
Osteo-Similar Modulus
PEEK is less rigid than titanium. PEEK's elastic modulus is closer to that of cortical bone (see chart above).4 Compared to all-titanium cages, PEEK cages have been shown to be six times less likely to experience subsidence.6
Proven STALIF Design
STALIF M FLX is built upon the simple, elegant design and proven success of the STALIF foundation.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f711e_hero_c-ti_integratedint.png)
No Profile®; No Supplemental Fixation
STALIF M-Ti's integrated cage and screw system is cleared for use without supplemental fixation, while the No-Profile® design allows it to nest fully within the confines of the vertebral body—leaving the anatomy unchanged external to the interbody.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f71db_hero_midlineii-ti_lagsmall.png)
The Lag Effect
Compressive lag fixation ensures biomechanical stability and provides secure graft-endplate contact. Lag screws reduce the vertebral bodies onto the cage creating graft / endplate surface compression to provide the best opportunity for fusion.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f7167_hero_midlineii-ti_bioequiv.png)
Biomechanical Equivalence
The STALIF M-Ti device is engineered to achieve equivalent biomechanical performance to anterior plate & cage, as well as posterior pedicle screw and cage, constructs.8
8Cappuccino A, et al. Multi-Directional Flexibility Properties of the STALIF MIDLINE(tm) Device. October 2011.
![](https://cdn.prod.website-files.com/651edf862c240fa1422f70b3/651edf862c240fa1422f71dc_hero_midlineii-ti_aboring.png)
Anti Back-Out® Screws
STALIF M-Ti™ screws provide an added layer of security with an Anti Back-Out® (ABO®) titanium split-ring which first compresses and then deploys during insertion.
Have questions?
ContactYou’ll find us knowledgeable, helpful, and almost always available. We remember what it was like to be a customer, too.